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Background & Aims of the Study: Oxidative stress increases platelet-derived growth factor (PDGF) gene expression in endothelial cells that contributes to vascular dysfunction and atherosclerosis. Oxidative stress generates by dys-regulated redox balance between ROS producing systems and antioxidant systems. Also, Curcumin (Cur) as a main part of turmeric has anti- inflammatory, antioxidant, anticancer and antitumor effects. This study was conducted to test the Curcumin as an environmental potent antioxidant decreases risk of arthrosclerosis.

Materials and Methods: This experimental study was conducted during 2015 in Iran. Cultured bovine aortic endothelial cells were incubated with hydrogen peroxide (H₂O₂) (20, 40 and 80 µM) and Curcumin (10 µM) for 24h. Then, the level of PDGF gene expression was analyzed by Real-Time PCR in untreated and treated cells.

Results: The results demonstrated significant increase in the level of PDGF gene expression in H₂O₂ treated groups versus control. Also, treated groups with H₂O₂ -Curcumin showed notable decrease in the level of PDGF gene expression compared with H₂O₂ treated groups.