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:: Volume 9, Issue 4 (Autumn 2020) ::
Arch Hyg Sci 2020, 9(4): 265-274 Back to browse issues page
Epidemiological Investigation of a Twenty-Year Major β-Thalassemia Surveillance in Kerman, Iran
Esmat Rezabeigi Davarani , Fatemeh Mohseni Takaloo , Azar Vahidnia , Salman Daneshi , Maryam Rezabeigi Davarani , Narges Khanjani * , Kiavash Hushmandi , Mehdi Raei
epartment of Epidemiology and Biostatistics, School of Public Health, Kerman University of Medical Sciences, Kerman, Iran
Abstract:   (8657 Views)
Background & Aims of the Study: Since beta-thalassemia is the most commonly inherited disease in Iran, its preventive and controlling programs are considered vitally important in the healthcare system. This study was conducted to investigate the incidence rate and epidemiology of major beta-thalassemia (MBT) over the last twenty years in Kerman, Iran.
Materials and Methods: This cross-sectional study, as a kind of health system research, carried was out on all patients with beta-thalassemia (born from March 1998 to March 2018) registered in Kerman Health Center. The data, extracted from the national records of genetic diseases, were analyzed in SPSS software (version 16) using Fisher's exact test.
Results: Based on the results of the present study, the incidence rate of MBT was calculated at 0.99 cases per 10,000 live births. According to this result, 29 subjects with MBT were born from 1998 to 2018. The most important cause of thalassemia was determined as non-identification of thalassemia minor in carrier couples and their lack of awareness about their complication (62%). The other cause was the non-cooperation of screened carrier couples in attending prenatal diagnosis (20.7%). It was revealed that in 23 MBT cases, the parents were relatives (79.3%). The diagnosis of 62% of patients had been made before they turned one year.
Conclusion: It is recommended that the following measures been adopted to avoid MBT incidence: strengthening the care team, cooperating with gynecologists in identifying pregnant women suspected of having thalassemia minor in the first weeks of pregnancy and referring them to genetic counseling centers for condition determination, educating families and changing carrier couples attitudes toward abortion, monitoring and improving screening laboratories, and implementing public education programs for specific groups.
Keywords: Thalassemia, Incidence, Prenatal Diagnosis, Consanguinity
Full-Text [PDF 576 kb]   (211 Downloads) |   |   Full-Text (HTML)  (295 Views)  
Type of Study: Original Article | Subject: Epidemiology
Received: 2020/08/12 | Accepted: 2020/09/21 | Published: 2020/10/1
1. Galanello R, Origa R. Beta-thalassemia. Orphanet journal of rare diseases. 2010; 5:11. Link: https://ojrd.biomedcentral.com/articles/10.1186/1750-1172-5-11 [DOI:10.1186/1750-1172-5-11]
2. Origa R. β-Thalassemia. Genetics in Medicine. 2017; 19(6):609-619. Link: https://www.nature.com/articles/gim2016173 [DOI:10.1038/gim.2016.173]
3. Khodaei GH, Farbod N, Zarif B, Nateghi S, Saeidi M. Frequency of thalassemia in Iran and Khorasan Razavi. International journal of Pediatrics. 2013; 1(1):45-50. Link: https://www.sid.ir/en/journal/ViewPaper.aspx?id=362606
4. Helmi N, Bashir M, Shireen A, Ahmed IM. Thalassemia review: features, dental considerations and management. Electronic physician. 2017; 9(3):4003-4008. Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407235/ [DOI:10.19082/4003]
5. Khorasani G, Kosaryan M, Vahidshahi K, Shakeri S, Nasehi MM. Results of the national program for prevention of β-thalassemia major in the Iranian Province of Mazandaran. Hemoglobin. 2008; 32(3): 263-271. Link: https://pubmed.ncbi.nlm.nih.gov/18473242/ [DOI:10.1080/03630260802004269]
6. Hassanzadeh J, Mirahmadizadeh A, Karimi M, Veisani Y, Rezaeian S. Trends in 5-, 10-, 20-, and 30-year survival rates of beta-thalassemia patients in Southern Iran, 1995-2016: A retrospective cohort study. Journal of public health research. 2017; 6(3): 153-157. Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737000/ [DOI:10.4081/jphr.2017.1001]
7. Esmaeilzadeh F, Azarkeivan A, Emamgholipour S, Akbari Sari A, Yaseri M, Ahmadi B, et al. Economic burden of thalassemia major in Iran, 2015. Journal of research in health sciences. 2016;16(3):111-115. Link: http://jrhs.umsha.ac.ir/index.php/JRHS/article/view/2746
8. Zeinalian M, Samavat A, Fadayee N, Azin S. Incidence rate of major beta-thalassemia and study of its causes after prevention and control program of thalassemia in Isfahan Province. Scientific Journal of Iranian Blood Transfusion Organization. 2009; 6(4):238-47.[ In Persian]. Link: http://bloodjournal.ir/browse.php?a_id=365&sid=1&slc_lang=en
9. Amirabadi F, Saravani S, Miri-Aliabad G, Khorashadi-Zadeh M. The Association between Dental Health Status and Oral Health-Related Quality of Life of Children Diagnosed with β-Thalassemia Major in Zahedan City, Iran. International Journal of Pediatrics. 2019; 7(2):8985-91. Link: http://ijp.mums.ac.ir/article_11475.html
10. Cappellini MD, Bejaoui M, Agaoglu L, Canatan D, Capra M, Cohen A, et al. Iron chelation with deferasirox in adult and pediatric patients with thalassemia major: efficacy and safety during 5 years' follow-up. Blood. 2011;118(4):884-93. Link: https://pubmed.ncbi.nlm.nih.gov/21628399/ [DOI:10.1182/blood-2011-09-377929]
11. Saliba AN, Harb AR, Taher AT. Iron chelation therapy in transfusion-dependent thalassemia patients: current strategies and future directions. Journal of blood medicine. 2015;6:197-209. Link: https://pubmed.ncbi.nlm.nih.gov/26124688/ [DOI:10.2147/JBM.S72463]
12. Sabloff M, Chandy M, Wang Z, Logan BR, Ghavamzadeh A, Li C-K, et al. HLA-matched sibling bone marrow transplantation for β-thalassemia major. Blood. 2011; 117(5):1745-50. Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056598/ [DOI:10.1182/blood-2010-09-306829]
13. Akhlaghpoor S. Chorionic villus sampling for beta‐thalassemia: the first report of experience in Iran. Prenatal Diagnosis: Published in Affiliation With the International Society for Prenatal Diagnosis. 2006; 26(12): 1131-6. Link: https://pubmed.ncbi.nlm.nih.gov/17009347/ [DOI:10.1002/pd.1572]
14. Rezabeigi Davarani E, Khanjani N, Iranpour A, Mohseni M, Najar Mansoori S. Educational needs of couples attending in pre-marriage counseling classes in health center of Kerman. Journal of Health Based Research 2016; 2: 69-80 [Persian]
15. Link: http://hbrj.kmu.ac.ir/browse.php?a_id=75&sid=1&slc_lang=en
16. Saleh-Gohari N, Bazrafshani M. Distribution of β-globin gene mutations in thalassemia minor population of Kerman Province, Iran. Iranian journal of public health. 2010; 39(2):69-76. Link: https://ijph.tums.ac.ir/index.php/ijph/article/view/3119
17. The Civil Registration. Link: https://www.sabteahval.ir
18. Khorasani G, Kosaryan M, Vahidshahi K, Shakeri S, Nasehi MM. Results of the national program for prevention of β-thalassemia major in the Iranian Province of Mazandaran. Hemoglobin. 2008;32(3):263-71. Link: https://www.tandfonline.com/doi/abs/10.1080/03630260802004269 [DOI:10.1080/03630260802004269]
19. Miri M, Tabrizi Namini M, Hadipour Dehshal M, Sadeghian Varnosfaderani F, Ahmadvand A, Yousefi Darestani S, et al. Thalassemia in Iran in last twenty years: the carrier rates and the births trend. Iranian journal of blood and cancer. 2013; 6(1): 11-17. Link: http://ijbc.ir/browse.php?a_id=432&sid=1&slc_lang=en
20. Hashemieh M, Naghadeh HT, Namini MT, Neamatzadeh H, Dehshal MH. The Iran thalassemia prevention program: success or failure? Iranian journal of pediatric hematology and oncology. 2015; 5(3): 161-166. Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688601/
21. Ghorbani Aliabadi E, Mirrashidi F, Kiani A shahrokhi sardoo E. Investigating the causes of Beta Thalassemia after Start of Prevention Program in Jiroft City during 2001-2015. Journal of Jiroft University of Medical Sciences. 2019; 6 (3): 168-77.[ In Persian] Link: http://journal.jmu.ac.ir/browse.php?a_id=222&sid=1&slc_lang=en
22. Miri-Moghaddam E, Fadaiy RM, Izadie SH. Lack of knowledge of being minor thalassemi is the main cause of major thalassemia incidence in Zahedan, the South-East of Iran 2011; 14: 174-179. [In Persian] Link: https://www.sid.ir/en/Journal/ViewPaper.aspx?ID=261678
23. Moafi A RS, Hourfar H, Shirani B. Evaluation of the causes of new cases of major thalassemia after screening for minor thalassemia in Isfahan. Journal Of Isfahan Medical School. 1383;22(73):11-14. [In Persian] Link: https://www.sid.ir/en/journal/ViewPaper.aspx?id=19827
24. Zare Z, Saffari E, Tabar RK. Fertility motivations and their relation with attitude towards Government incentives for childbearing in women of reproductive age. Journal of Mazandaran University of Medical Sciences. 2018;28(162):104-14. Link: https://www.sid.ir/en/Journal/ViewPaper.aspx?ID=610097
25. Badieian Mosavi N, Hejazi SA, Sadeghipour F, Fotovat A, Hoseini M. Examination of Fetal Indications in 548 Cases of Abortion Therapy Permissions Issued by Forensic Medicine Center of Razavi Khorasan, Iran, in 2015. The Iranian Journal of Obstetrics, Gynecology and Infertility. 2018;21(5):6-13. Link: http://eprints.mums.ac.ir/10217/
26. Hassanzadeh J, Mirahmadizadeh A, Karimi M, Rezaeian S. Delay in diagnosis of hemoglobulinopathies (thalassemia, sickle cell anemia): A need for management of thalassemia programs. Iranian Journal of Pediatrics. 2017; 27(2):e6740. Link: https://sites.kowsarpub.com/ijp/articles/6740.html [DOI:10.5812/ijp.6740]
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Rezabeigi Davarani E, Mohseni Takaloo F, Vahidnia A, Daneshi S, Rezabeigi Davarani M, Khanjani N, et al . Epidemiological Investigation of a Twenty-Year Major β-Thalassemia Surveillance in Kerman, Iran. Arch Hyg Sci. 2020; 9 (4) :265-274
URL: http://jhygiene.muq.ac.ir/article-1-466-en.html

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