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Arch Hyg Sci 2020, 9(2): 88-96 Back to browse issues page
Epidemiology and Clinical Characteristics of Ulcerative Colitis in Chaharmahal and Bakhtiari Province, Iran
Hamid Gheibipour , Ali Ahmadi * , Ghorbanali Rahimian
b Department of Epidemiology and Biostatistics, Faculty of Public Health, Shahrekord University of Medical Sciences, Shahrekord, Iran
Abstract:   (789 Views)
Background & Aims of the Study: Ulcerative colitis (UC) is an inflammatory bowel disease, which is spreading continuously. This study aimed to determine the epidemiologic profile of the patients with UC in Chaharmahal and Bakhtiari province, Iran, as a database for other researches.
Materials and Methods: This descriptive cross-sectional study was performed on the profiles of the patients with a definitive diagnosis of UC during 2012-2016 in Chaharmahal and Bakhtiari in 2019. All the samples were selected through the census method. The data consisted of demographic characteristics, clinical features, as well as colonoscopy and histopathology results, and other symptoms which were collected based on the checklists. The data were analyzed in SPSS software (version 22); moreover, the qualitative and quantitative variables were reported using frequency and percentage as well as mean and standard deviation, respectively.
Results: This study analyzed 177 UC patients with a mean age of 38.31±11.69 years. According to the findings, the 31-40-year-old group was the most vulnerable age group. Regarding gender, 59.3% of the patients were male. The mean duration between the onset of the symptoms and diagnosis was reported as 7±11.51 years. The most common symptoms were bleeding (72%) and abdominal pain (53%). Moreover, erythema (63.27%) and erosion (54.8%) were the most prevalent complications based on the pathologic findings. Extra-intestinal manifestations were reported among 18.36% of the cases. Considering the involved locations, pancolitis (36.72%) and the inflammation of rectosigmoid (35.6%) were the most common types.
Conclusion: The results of this study were similar to the findings of other investigations in terms of demographic characteristics. On the other hand, the clinical symptoms and complications of the disease were different from those in some previous studies.
Keywords: : Epidemiology, Ulcerative Colitis (UC), Inflammatory Bowel Disease (IBD), Chaharmahal and Bakhtiari
Full-Text [PDF 424 kb]   (164 Downloads) |   |   Full-Text (HTML)  (195 Views)  
Type of Study: Original Article | Subject: Epidemiology
Received: 2019/10/7 | Accepted: 2019/12/21 | Published: 2020/05/30
References
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18. Zahedi MJ, Darvish-moghadam S, Haiatbakhsh M, Dalirsani Z. Demographic and Clinical Features of Ulcerative Colitis Patients in Kerman City during 2005-2007. Journal of Kerman University of Medical Sciences. 2015; 16(1): 45-53. link
19. Amani F, Sadeghi Movahed V, Tabarraie Y. Epidemiologic study of 80 Patients with Ulcerative Colitis refereed to Imam Hospital in Ardabil City during 2004-2010. Advances in Bioresearch. 2014;5(1):131-136. link
20. Malekzadeh MM, Vahedi H, Gohari K, Mehdipour P, Sepanlou SG, Ebrahimi Daryani N, et al. Emerging epidemic of inflammatory bowel disease in a middle income country: A nation-wide study from Iran. Archives of Iranian medicine. 2016; 19 (1):1-14. link
21. Sharma J, Sharma B, Sharma R, Mahajan S, Raina R, Sharma P. The profile of inflammatory bowel disease in natives of Western Himalayas. Tropical Gastroenterology. 2017;38(2):115-21. link [DOI:10.7869/tg.408]
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25. Larsen S, Bendtzen K, Nielsen OH. Extraintestinal manifestations of inflammatory bowel disease: epidemiology, diagnosis, and management. Annals of medicine. 2010;42(2):97-114. link [DOI:10.3109/07853890903559724]
26. Levine JS, Burakoff R. Extraintestinal manifestations of inflammatory bowel disease. Gastroenterology & hepatology. 2011;7(4):235. link
27. Evans PE, Pardi DS. Extraintestinal manifestations of inflammatory bowel disease: focus on the musculoskeletal, dermatologic, and ocular manifestations. Medscape General Medicine. 2007;9(1):55. link
28. Bernstein CN, Blanchard JF, Rawsthorne P, Yu N. The prevalence of extraintestinal diseases in inflammatory bowel disease: a population-based study. The American journal of gastroenterology. 2001;96(4):1116-22. link [DOI:10.1111/j.1572-0241.2001.03756.x]
29. Ricart E, Panaccione R, Loftus Jr EV, Tremaine WJ, Harmsen WS, Zinsmeister AR, et al. Autoimmune disorders and extraintestinal manifestations in first‐degree familial and sporadic inflammatory bowel disease. A case-control study. Inflammatory bowel diseases. 2004;10(3):207-214. link [DOI:10.1097/00054725-200405000-00005]
30. Danese S, Semeraro S, Papa A, Roberto I, Scaldaferri F, Fedeli G, et al. Extraintestinal manifestations in inflammatory bowel disease. World Journal of Gastroenterology. 2005;11(46):7227. link [DOI:10.3748/wjg.v11.i46.7227]
31. Mendoza J, Lana R, Taxonera C, Alba C, Izquierdo S, Díaz-Rubio M. Extraintestinal manifestations in inflammatory bowel disease: differences between Crohn's disease and ulcerative colitis. Medicina clínica. 2005;125(8):297-300. link [DOI:10.1157/13078423]
32. Farmer RG, Easley KA, Rankin GB. Clinical patterns, natural history, and progression of ulcerative colitis. Digestive diseases and sciences. 1993;38(6):1137-46. link [DOI:10.1007/BF01295733]
33. Fakhoury M, Negrulj R, Mooranian A, Al-Salami H. Inflammatory bowel disease: clinical aspects and treatments. Journal of inflammation research. 2014;7:113. link [DOI:10.2147/JIR.S65979]
34. Andersen V, Olsen A, Carbonnel F, Tjønneland A, Vogel U. Diet and risk of inflammatory bowel disease. Digestive and liver disease. 2012;44(3):185-94. link [DOI:10.1016/j.dld.2011.10.001]
35. Cosnes J, Gower-Rousseau C, Seksik P, Cortot A. Epidemiology and natural history of inflammatory bowel diseases. Gastroenterology. 2011;140(6):1785-94. e4. link [DOI:10.1053/j.gastro.2011.01.055]
36. Molodecky NA, Soon S, Rabi DM, Ghali WA, Ferris M, Chernoff G, et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology. 2012;142(1):46-54. e42. link [DOI:10.1053/j.gastro.2011.10.001]
37. Bernstein CN, Blanchard JF, Rawsthorne P, Wajda A. Epidemiology of Crohn's disease and ulcerative colitis in a central Canadian province: a population-based study. American journal of epidemiology. 1999;149(10):916-24. link [DOI:10.1093/oxfordjournals.aje.a009735]
38. Ng SC, Tang W, Ching JY, Wong M, Chow CM, Hui A, et al. Incidence and phenotype of inflammatory bowel disease based on results from the Asia-pacific Crohn's and colitis epidemiology study. Gastroenterology. 2013;145(1):158-65. e2. link [DOI:10.1053/j.gastro.2013.04.007]
39. Prideaux L, Kamm MA, De Cruz PP, Chan FK, Ng SC. Inflammatory bowel disease in Asia: a systematic review. Journal of gastroenterology and hepatology. 2012;27(8):1266-80. link [DOI:10.1111/j.1440-1746.2012.07150.x]
40. Thia KT, Loftus Jr EV, Sandborn WJ, Yang S-K. An update on the epidemiology of inflammatory bowel disease in Asia. The American journal of gastroenterology. 2008;103(12):3167. link [DOI:10.1111/j.1572-0241.2008.02158.x]
41. Shayesteh AA, Saberifirozi M, Abedian S, Sebghatolahi V. Epidemiological, demographic, and colonic extension of ulcerative colitis in Iran: a systematic review. Middle East journal of digestive diseases. 2013;5(1):29. link
42. Zahedi MJ, Moghadam SD, Abbasi MHB, Dehghani M. The incidence rate of inflammatory bowel disease in an urban area of iran: a developing country. Middle East journal of digestive diseases. 2014;6(1):32. link
43. Kurina L, Goldacre M, Yeates D, Gill L. Depression and anxiety in people with inflammatory bowel disease. Journal of Epidemiology & Community Health. 2001;55(10):716-20. link [DOI:10.1136/jech.55.10.716]
44. Corrao G, Tragnone A, Caprilli R, Trallori G, Papi C, Andreoi A, et al. Risk of inflammatory bowel disease attributable to smoking, oral contraception and breastfeeding in Italy: a nationwide case-control study. International journal of epidemiology. 1998;27(3):397-404. link [DOI:10.1093/ije/27.3.397]
45. Aghazadeh R, ZALI MR, BAHARI A, Amin K, Ghahghaei F, Firouzi F. Inflammatory bowel disease in Iran: A review of 448 cases. 2004. link
46. Mohammadi H, Airamloo M. Clinical and epidemiological characteristics in ulcerative colitis patients referred to Imam Hospital, 1995-2000. Tehran University Medical Journal TUMS Publications. 2001;59(4):80-5. link
47. Epidemiologic Characteristics and Frequency of Anatomical Pattern of Ulcerative Colitis in Patients Referred to Imam Khomeini Hospital During Years 2007 to 2011 .1393; 3(13). 276-282. link
48. Ghadiri A, Esmaeili H, Hashemi SJ, Masjedizadeh A, Alavinejad P, Shayesteh AA. A Study on Epidemiological Features and Clinical Manifestations among Crohn and Ulcerative Colitis Patients Admitted to Treatment Centers of Ahvaz, Iran. Jundishapur Scientific Medical Journal. 2016;15(1):19-33. link
49. Zahedi MJ, Darvish-moghadam S, Haiatbakhsh M, Dalirsani Z. Demographic and Clinical Features of Ulcerative Colitis Patients in Kerman City during 2005-2007. Journal of Kerman University of Medical Sciences. 2015; 16(1): 45-53. link
50. Amani F, Sadeghi Movahed V, Tabarraie Y. Epidemiologic study of 80 Patients with Ulcerative Colitis refereed to Imam Hospital in Ardabil City during 2004-2010. Advances in Bioresearch. 2014;5(1):131-136. link
51. Malekzadeh MM, Vahedi H, Gohari K, Mehdipour P, Sepanlou SG, Ebrahimi Daryani N, et al. Emerging epidemic of inflammatory bowel disease in a middle income country: A nation-wide study from Iran. Archives of Iranian medicine. 2016; 19 (1):1-14. link
52. Sharma J, Sharma B, Sharma R, Mahajan S, Raina R, Sharma P. The profile of inflammatory bowel disease in natives of Western Himalayas. Tropical Gastroenterology. 2017;38(2):115-21. link [DOI:10.7869/tg.408]
53. Makharia GK, Ramakrishna BS, Abraham P, Choudhuri G, Misra SP, Ahuja V, et al. Survey of inflammatory bowel diseases in India. Indian Journal of Gastroenterology. 2012;31(6):299-306. link [DOI:10.1007/s12664-012-0258-1]
54. Ghanadi K, Valizadeh J, Hasanvand A. Epidemiological and clinical aspects of ulcerative colitis in west of Iran: a cross sectional study. SpringerPlus. 2016;5(1):1588. link [DOI:10.1186/s40064-016-3248-4]
55. Vavricka SR, Schoepfer A, Scharl M, Lakatos PL, Navarini A, Rogler G. Extraintestinal manifestations of inflammatory bowel disease. Inflammatory bowel diseases. 2015;21(8): 1982-1992. link [DOI:10.1097/MIB.0000000000000392]
56. Larsen S, Bendtzen K, Nielsen OH. Extraintestinal manifestations of inflammatory bowel disease: epidemiology, diagnosis, and management. Annals of medicine. 2010;42(2):97-114. link [DOI:10.3109/07853890903559724]
57. Levine JS, Burakoff R. Extraintestinal manifestations of inflammatory bowel disease. Gastroenterology & hepatology. 2011;7(4):235. link
58. Evans PE, Pardi DS. Extraintestinal manifestations of inflammatory bowel disease: focus on the musculoskeletal, dermatologic, and ocular manifestations. Medscape General Medicine. 2007;9(1):55. link
59. Bernstein CN, Blanchard JF, Rawsthorne P, Yu N. The prevalence of extraintestinal diseases in inflammatory bowel disease: a population-based study. The American journal of gastroenterology. 2001;96(4):1116-22. link [DOI:10.1111/j.1572-0241.2001.03756.x]
60. Ricart E, Panaccione R, Loftus Jr EV, Tremaine WJ, Harmsen WS, Zinsmeister AR, et al. Autoimmune disorders and extraintestinal manifestations in first‐degree familial and sporadic inflammatory bowel disease. A case-control study. Inflammatory bowel diseases. 2004;10(3):207-214. link [DOI:10.1097/00054725-200405000-00005]
61. Danese S, Semeraro S, Papa A, Roberto I, Scaldaferri F, Fedeli G, et al. Extraintestinal manifestations in inflammatory bowel disease. World Journal of Gastroenterology. 2005;11(46):7227. link [DOI:10.3748/wjg.v11.i46.7227]
62. Mendoza J, Lana R, Taxonera C, Alba C, Izquierdo S, Díaz-Rubio M. Extraintestinal manifestations in inflammatory bowel disease: differences between Crohn's disease and ulcerative colitis. Medicina clínica. 2005;125(8):297-300. link [DOI:10.1157/13078423]
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Gheibipour H, Ahmadi A, Rahimian G. Epidemiology and Clinical Characteristics of Ulcerative Colitis in Chaharmahal and Bakhtiari Province, Iran. Arch Hyg Sci. 2020; 9 (2) :88-96
URL: http://jhygiene.muq.ac.ir/article-1-422-en.html
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